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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8391cdf42301dc7e85246aec7ef565e9ec427b15de2c09676638a48964e2e386' 
  AND token = 'qU2GIxMa7lQcZ+99k+q3HbwCmBMsnHcrXO/+sJeHriM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}