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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2ae1c48d69de419e7b78d14db1a5bf41e1424e9180a9e1d02aa0119c42386942' 
  AND token = '8eQnuvs7wB4RI3HFYmy+v7OkKnNXctM5V4RkMGnp7EY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}