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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '10cdb585ad01af68c0532f302919948cfa3b017a0f7b4522f4d67cdcfb42e918' 
  AND token = 'NjaAzTcVjrU811TgPvNNyf1mrGqTuLQkGDWbBZ6qnlk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}