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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9bc88bdb45d20f2bdcbeb18ba2d8b2f58e04d147a7a188e2924215511aad7224' 
  AND token = 'EsklgOLDtJ2bXF3SAP/xG2Lzk1NFNCFqeHBcoo3X5I0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}