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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2ad3d5f649b5bb85c0366d84678b821022b2445eed42a06ba67eeb24cc344a1d' 
  AND token = 'WIXg8Rl3Zm2O6iS2849TQFa59JtEKM0v1hhQKdG82OQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}