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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '649550e5d16eb351420a52f6c2c48d0643e6021eb2f1d919476f430f588bdfa9' 
  AND token = 'FSz4sj76iUUd/7OGxPsE6tgA8rdR1fgJL6T3gxGrDXU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}