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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '396d6f7650e259644e8f2e79c39961bb72e49e57f3f9cb9a133447a3e27e0d16' 
  AND token = '/v7Fv4YFtxnZwjM4E9dOh7PD2HsxqmdpxDFddgBtI+Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}