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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2fd9f8c906a825251a7a34e81b755563a5f573031bc041d38197c956b19a837e' 
  AND token = 'VnIEuo+yvoIrCZOmVNEOIsG1SRiEBVo0uwu6twT7fuQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}