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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e9b2078b0c5464d11ca5e1304b39eba222f1ba409d3e5edcb94f295a004a2155' 
  AND token = 'I8/b2iAMk+k92xfxrWzMkIwaS3TJKn65Tg5V+Lr0dq0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}