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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '721affbad7a1035380b0d43b99825265b2f26210357b05e0fda4e690c4715767' 
  AND token = '3i49H5kn9AAK2HwbVHWOJuVzhuDfH0gE0E+mw6SoW40=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}