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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '10686a2b95ee2c9e9594b527900f747a6f475e4deb6ff3040f77901883840f21' 
  AND token = '25pCNvj3qJ81m/R0U7+y0BRctYzzDUw+zymwdDASa3A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}