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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1f75eef61e8636942f1648ff8f71515c40e219f72793f02ea759f99fde860725' 
  AND token = 'xFd6v3Brk9N98ArBQ2XmwpA+B1KoW0gD51/+Pc6Jm1g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}