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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '65cdc21c7a56744fe2541a862f0e479db4a25d26df6e39f1fd9f6aa0d138afd5' 
  AND token = 'dlRHIsv16VSj3+NYc0ZVmpMkL3oj5Hc8PZUAc4hHmZc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}