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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '449223b9a868345a59d440894b901cac6153c02b1fbfe38b5d1af3602c665221' 
  AND token = '6V8cyV2Gj4XNNrS07SfT7FAIL96i4fPiyMpzWpObnXg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}