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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22165d626f8f001c18d08d606b7875c46fea078eec5efc5379864f7d2743d601' 
  AND token = '0HHoPSIJUmF3eyt1nra9Q0WJxZD/maLyMcatG2VCWRc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}