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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3c8a551a6135e1c6507fd6fa89cabe456fb1bd04d78882bb95df32a46f346508' 
  AND token = 'kN65HU+EBmA91dCeEV3b+VuvkxoceykuuuC1IkzzXnE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}