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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4a6b21b5555bbb26179459eef8aae97e30500b5b2ae54cb0bc955b9c82e4d891' 
  AND token = 'S5u5H9KkaW6iQ1Vaumx/X0UOsTP88CnebS/u0uY0lBY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}