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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '39f58c87bc3d3a2e05dd5734e4a2182d173525148a413629019cdbf150e4854c' 
  AND token = 'AweLburOkcCoArTR36jjrv1pArRTlYozl14soRXnCI8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}