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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '946a992e42c1c39a8c5d2587b29340334b4bab1992c6fca6b4ec1570f069ea0f' 
  AND token = 'u1M2QgCJFj5xqmjDfIMq2p9WjTcw8EPCXMTMdOijaGQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}