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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5fef40461d83b4e80a1c3cd5e17e255fefb5f559a3ee3f37f38bab9f7d308f59' 
  AND token = 'Qw9oCUHuI0xqjvrzTjpon0iQ7gm0fqxa+RdHCgLA0m4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}