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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2a61f3feb7c5d96fe45a85e62a23ef83dcad6ce699ee685b3b261ab777b880f4' 
  AND token = 'R3ZUUlwR8yI5QlcR5eH9K1vLPIl9pHsjIe1Y4y7nezU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}