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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43a6f0523152f5e6664b910e89f184bb0403e180a1c3da516647350f5b978bd9' 
  AND token = '5cIIU72wBLnPovpr5Sw8gnA0+MxuT37xoYXPk2NW/K0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}