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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '46f2dbce4e4dc57572c0680f9eac0286f9a97d68d7f9c12d335f576a16581eca' 
  AND token = 'HPMSYz+5k4bIcSvbr8LO22WgEtFCh0xmIeE5wQxx6Kc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}