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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5e41b96b0a979b92a56f1dbcce6dd6774aadfb43e5d36fec660080ec336070d9' 
  AND token = '7ihmrB5uyAOLn/Tv/DwuR1CNVzVMxAaTaofMrzr7tC0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}