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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8ea72648563000fa20e3059b99c7018b363f729d86619c2dd3a52411fd5a8e12' 
  AND token = 'BIAOU2P9fl58p6eKVrHYmxNrmWv3apueYNVzNQiL6Ts=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}