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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43407919b5a598fab5fb973ff2887634e3a3b82a8680fffebe5b88671ae8b365' 
  AND token = 'eSZp9HmG+LlCCsO8QXh8q9VaNVtuWSXwSRdLWkcBg1M=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}