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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b161ba4fbfc5928907dc3814cd1a46011e69bbe6f134c1a37c185dea88b40d07' 
  AND token = 'ni3iy4nLz4Wc9dxdzSiFkDAHpXsHeD7E4psKTd265Zk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}