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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3cd2ad979be324ccaa00e3f7107c64597fb8c91cc8d8502c7cecfcf263365464' 
  AND token = 'MU6l7I0lKRFrW8x4T1HJtmq4tTUYGuWQTziIVToXL4Q=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}