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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8c4600d8021f35d9b6e05a9ae8c9a2fe92a1acb641c5b21ee4c1053532486811' 
  AND token = 'IBwOrv52zfPzqObtRRSHP4sv4tHb3MleZX71gndHRd4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}