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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5d60210b8be9733d1520c89d508753d8d305cb00a2c031f2b6148b69d0c3e2c7' 
  AND token = 'I5OLux/PR9yZ/DAbdTc4KDFPfr/T3SNdRXPIXymaS0M=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}