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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '180bf8469908e7c8b9c93d7dec7c218bc9e30229cb7fe859943f5d920bf29e12' 
  AND token = 'YjRs7Mvxf0vSj8XUt4WWWBzGFvczHD00C8QdW94+aYQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}