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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '80018315137dc297cfd76c4638a44f9243c2e571421ba5e0953a632dc78bf539' 
  AND token = 'FDw5R7KSt+sv0JvH79wyeg2Lvk3gJW2Plx+Xf3jRLz0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}