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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '50925b04cff8f10a62fbb7a7e2b3050223c9e4c3634f0e98bb4de1eb39a7d42d' 
  AND token = 'ie71VdXL+yzjAn92O1DPoBzC90tgrzirz/B39nF2BRc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}