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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '104fb51e67f392c76a65d058728fca87ec94130fc6f934fef306b47a7ad25c00' 
  AND token = 'NO9U1cLh3kWbyk+FbWyO/lDXR9u1wW+im8pomg7GSkw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}