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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49e879a40f6a8ba86eab02ddc9bcea414b5e950b5408ff2d7296ce128a8300e4' 
  AND token = 'iyVJCt9Sv2ak3MHca5E1mxrt0NqrEZYAZSh5vf+JbLU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}