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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '250d972cfd323685152b0a0e8d7221c64c129abdd61da1225325069c33c60bbb' 
  AND token = 'jIYKy6996zvu9hvFKXtqN2Jv0tfH5+v3E1DD7e9yK4o=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}