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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5d91ee55ff438faf14da8bc6aa4bee8f1b226bde336eadcb15e7747be6794418' 
  AND token = 'NqSLBTXHx9QhQFBOyKRHDWUjn0hpD7BSNDrRPi3IQIY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}