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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4ec9026b3ecc5dc3ba89a9fc525fc997cc91f110c4b93a17c174418d220e4b64' 
  AND token = 'ZCj6pAKwo7m27fuL/AOKtlxNM4uYG7A9d6g/QyqjfzU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}