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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '46e6d5934701379d550a92c08f805a15f50e0e16eb831d35f578404abb50ef8c' 
  AND token = 'E+JERP2eDXX17nKSmAtZCAk8etW8YECfDYwpBJQe3Z8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}