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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '65dd0e10919844c67e52aca37464c7b1db6fc05d31a994f23549b1c68737e5bc' 
  AND token = 'tdMjTC1t3D4Wpr/fAr+0vc0C2oTL/Pwsz51VVwRgM3o=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}