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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9d59f89f648b17115a28b2b105f4251558923cc8690a85f020e8467436c5c022' 
  AND token = 'iCVdCASYsL0WNXJtpAAnjpRp+A3b3EqY/HIiuW1k1P8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}