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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4f5f43ef4b4b58715f075f408c04dc18162cc5d24da709bd7b0364b4fb044478' 
  AND token = 'MCVDVcfmakuSXvcpbpwuCOSf+sGpxgHDhbPSL0xt2ZE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}