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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a4cceb4d7900286b7f0a889930d68743b25235fd1eb6695044ab55551723e7b1' 
  AND token = 'BGRkjx4UaY7BpMnB9t0PW8B3HV55bEoHlZ7Oxfy34fg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}