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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '57ea877c28ebf868a4f1ad61a325816ad0be5fff71b4e5e52f5abbade61550e5' 
  AND token = 'fqjiOGZzYPtAYRw4qfVUGvfoIN13w8rkqPF5BuTjJ/o=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}