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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '465d0f7a482d64e7bb6409cb5a08548b00c2a7a9fa22a5644804da5bb5f9061b' 
  AND token = 'W7JQTVTTuCSPa76WLW/7kWUwrV6/ZGxrxa+PosxLWxM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}