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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '16b511826728a7f5f8bb5049c1cf727f14e1c8f6d48219448f9e93e660076666' 
  AND token = 'EsTZ0Nxzr7Qh0nzWZRaocup2w4IHzVbZYSrh30ExC4U=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}