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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3757166ac3246281a918f12a87f229a6bfc53d893fa27aaeb1b740b4af3369b6' 
  AND token = 'Yq8qbBKBnunbUc2JE1duaza4Y2LzHZ2y/ATCXB0dWT4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}