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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c8290e3b5d2596b2c0126a671f79296a70254d2ca91ccf60a16c494c145be67c' 
  AND token = 'IZMsPfpYIS9/M0229YBc0SOrn+HvO6RzAHX/Qsr+hQ0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}