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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8fe7be01cfa6c58e1b7c30c029408ba2be833cf559be7689ebd8a76c97e9a204' 
  AND token = '2e1UzBzdepgs4N7OrvpB8v4fD7+KTbLpRBS4WZY7Wg8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}