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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5889f8ca880d737f3a7645ac1788b2d2169d7cf110fda60b5e4e848bcd726094' 
  AND token = 'S5R+eLTgSuim+dpku8u58YWPnKGou2NribUwmm3WfMc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}